Jamming during the discharge of granular matter from a silo

In this work we present an experimental study of the jamming that stops the free flow of grains from a silo discharging by gravity. When the outlet size is not much bigger than the beads, granular material jams the outlet of the container due to the formation of an arch. Statistical data from the number of grains fallen between consecutive jams are presented. The information that they provide can help to understand the jamming phenomenon. As the ratio between the size of the orifice and the size of the beads is increased, the probability that an arch blocks the outlet decreases. We show here that there is a power law divergence of the mean avalanche size for a finite critical radius. Beyond this critical radius no jamming can occur and the flow is never stopped. The dependence of the arch formation on the shape and the material of the grains has been explored. It has been found that the material properties of the grains do not affect the arch formation probability. On the contrary, the shape of the grains deeply influences it. A simple model to interpret the results is also discussed.Comment: Submitted to Phys. Rev.

Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog

The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct morphology and combination of AVCD features in some of these syndromes is reminiscent of the cardiac phenotype found in heterotaxy, a malformation complex previously associated with functional cilia abnormalities and aberrant Hedgehog (Hh) signaling. Hh signaling coordinates multiple aspects of left-right lateralization and cardiovascular growth. Being active at the venous pole the secondary heart field (SHF) is essential for normal development of dorsal mesenchymal protrusion and AVCD formation and septation. Experimental data show that perturbations of different components of the Hh pathway can lead to developmental errors presenting with partially overlapping manifestations and AVCD as a common denominator. We review the potential role of Hh signaling in the pathogenesis of AVCD in different genetic disorders. AVCD can be viewed as part of a "developmental field," according to the concept that malformations can be due to defects in signal transduction cascades or pathways, as morphogenetic units which may be altered by Mendelian mutations, aneuploidies, and environmental causes

Arches and contact forces in a granular pile

Assemblies of granular particles mechanically stable under their own weight contain arches. These are structural units identified as sets of mutually stable grains. It is generally assumed that these arches shield the weight above them and should bear most of the stress in the system. We test such hypothesis by studying the stress born by in-arch and out-of-arch grains. We show that, indeed, particles in arches withstand larger stresses. In particular, the isotropic stress tends to be larger for in-arch-grains whereas the anisotropic component is marginally distinguishable between the two types of particles. The contact force distributions demonstrate that an exponential tail (compatible with the maximization of entropy under no extra constraints) is followed only by the out-of-arch contacts. In-arch contacts seem to be compatible with a Gaussian distribution consistent with a recently introduced approach that takes into account constraints imposed by the local force balance on grains.Comment: 7 pages, 7 figures, major revisio

Intruder in a two-dimensional granular system: statics and dynamics of force networks in an experimental system experiencing stick-slip dynamics

In quasi-two-dimensional experiments with photoelastic particles confined to an annular region, an intruder constrained to move in a circular path halfway between the annular walls experiences stick-slip dynamics. We discuss the response of the granular medium to the driven intruder, focusing on the evolution of the force network during sticking periods. Because the available experimental data does not include precise information about individual contact forces, we use an approach developed in our previous work (Basak et al, J. Eng. Mechanics (2021)) based on networks constructed from measurements of the integrated strain magnitude on each particle. These networks are analyzed using topological measures based on persistence diagrams, revealing that force networks evolve smoothly but in a nontrivial manner throughout each sticking period, even though the intruder and granular particles are stationary. Characteristic features of persistence diagrams show identifiable changes as a slip is approaching, indicating the existence of slip precursors. Key features of the dynamics are similar for granular materials composed of disks or pentagons, but some details are consistently different. In particular, we find significantly larger fluctuations of the measures computed based on persistence diagrams, and therefore of the underlying networks, for systems of pentagonal particles

Phytochemical profiling, antibacterial and antioxidant properties of Crocus sativus flower: A comparison between tepals and stigmas

Several studies have demonstrated that stigmas of Crocus sativus contain several bioactive compounds with potential health-promoting properties. However, during the processing of stigmas, large amounts of floral bio-residues are normally discarded as by-products. In this study, using untargeted metabolomics, the comprehensive phytochemical composition of C. sativus stigma and tepals was investigated. Moreover, the antibacterial and anti-biofilm properties of the extracts of C. sativus stigmas and tepals were compared. The study was carried out using two methicillin-resistant staphylococcal reference strains (i.e., Staphylococcus aureus ATCC 43300 and Staphylococcus epidermidis ATCC 35984), representing important Gram-positive biofilm-forming human pathogens. The antibacterial properties were correlated with total polyphenol content, total terpenoid content, and in vitro antioxidant properties of tepals and stigmas. The results demonstrated that stigma and tepal extracts, at the sub-toxic concentrations, were able to interfere with biofilm formation by ATCC 43300 and ATCC 35984. Besides, the higher antibacterial activity of tepals than stigmas was associated with higher levels of phycompounds. Therefore, our results demonstrated that C. sativus stigmas and bio-residues, such as tepals, are potential antioxidant sources and good candidates as antibacterial agents to prevent biofilm formation. Taken together, these findings showed that C. sativus could be used as functional ingredient by the food and pharmaceutical industries

Cooperativity in sandpiles: statistics of bridge geometries

Bridges form dynamically in granular media as a result of spatiotemporal inhomogeneities. We classify bridges as linear and complex, and analyse their geometrical characteristics. In particular, we find that the length distribution of linear bridges is exponential. We then turn to the analysis of the orientational distribution of linear bridges and find that, in three dimensions, they are {\it vertically diffusive but horizontally superdiffusive}; thus, when they exist, long linear bridges form `domes'. Our results are in good accord with Monte Carlo simulations of bridge structure; we make predictions for quantities that are experimentally accessible, and suggest that bridges are very closely related to force chains.Comment: 15 pages, 10 figures. Minor changes and update

Perilaku Konsumtif Masyarakat Kota (Studi Kasus di Masyarakat Kopo Kel. Cirangrang Kec. Babakan Ciparay, Kota Bandung)

Masalah dalam penelitian ini adalah masyarakat Cirangrang kurang terkontrol dalam membelanjakan uangnya sehingga timbul perilaku konsumtif yang berlebihan. Gaya hidup konsumtif terlihat pada kebiasaan mereka yang selalu berbelanja dengan jumlah yang banyak, harga yang cukup mahal dan berbelanja di mall. Baik menengah ke atas, menengah dan menengah ke bawah atau pendapatan tinggi dan rendah memiliki gaya hidup konsumtif. ditambah dengan banyaknya media-media yang menawarkan berbagai macam produk menarik. Faktor gengsi dan ingin berusaha mengikuti trend yang sedang beredar menjadi alasan masyarakat memiliki perilaku konsumtif. Pentingnya penulis melakukan penelitian ini adalah bertujuan untuk mengetahui pola perilaku konsumtif masyarakat Cirangrang dan untuk mengetahui factor-faktor penyebab masyarakat Cirangrang berperilaku konsumtif. Teori yang digunakan dalam analisis data penelitian ini adalah teori Jean Baudrillard tentang masyarakat konsumsi. Dalam masyarakat konsumsi jika masyarakat memiliki uang maka mereka bebas mengkonsumsi apa yang mereka inginkan. Namun dalam hal ini mereka bebas untuk mengkonsumsi hanya semata-mata pada objek dan tanda yang berbeda-beda. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif dengan jenis data primer data yang diperoleh langsung dari objek penelitian. Data yang dikumpulkan dalam penelitian ini merupakan data primer dan data sekunder dengan menggunakan teknik pengumpulan data: Observasi dan wawancara. Hasil penelitian ini adalah masyarakat yang memiliki perilaku konsumtif dapat dilihat beberapa kriteria diantaranya, Frekuensi belanja : setiap weekend, satu bulan sekali atau ketika memiliki uang. Kemudian kriteria dalam memilih barang pada dasarnya memilih yang bermerk, dan dan tidak bermerk namun memilih modelnya yang menarik. Lokasi belanja yang dikunjungi masyarakat Cirangrang biasanya adalah mall, distro, butik dan outlate. Biaya yang dikeluarkan untuk berbelanja cukup besar yaitu berkisar Rp 150.000- Rp.1.000.000. Faktor-faktor penyebab masyarakat Cirangrang berperilaku konsumtif adalah ingin menjaga gengsi, menarik perhatian orang lain, mengikuti Trend yang ada, dan banyaknya diskon menarik

Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress

<p>Abstract</p> <p>Background</p> <p>Considerable interest has been aroused in recent years by the well-known notion that biological systems are sensitive to visible light. With clinical applications of visible radiation in the far-red to near-infrared region of the spectrum in mind, we explored the effect of coherent red light irradiation with extremely low energy transfer on a neural cell line derived from rat pheochromocytoma. We focused on the effect of pulsed light laser irradiation vis-à-vis two distinct biological effects: neurite elongation under NGF stimulus on laminin-collagen substrate and cell viability during oxidative stress.</p> <p>Methods</p> <p>We used a 670 nm laser, with extremely low peak power output (3 mW/cm²) and at an extremely low dose (0.45 mJ/cm²). Neurite elongation was measured over three days in culture. The effect of coherent red light irradiation on cell reaction to oxidative stress was evaluated through live-recording of mitochondria membrane potential (MMP) using JC1 vital dye and laser-confocal microscopy, in the absence (photo bleaching) and in the presence (oxidative stress) of H₂O₂, and by means of the MTT cell viability assay.</p> <p>Results</p> <p>We found that laser irradiation stimulates NGF-induced neurite elongation on a laminin-collagen coated substrate and protects PC12 cells against oxidative stress.</p> <p>Conclusion</p> <p>These data suggest that red light radiation protects the viability of cell culture in case of oxidative stress, as indicated by MMP measurement and MTT assay. It also stimulates neurite outgrowth, and this effect could also have positive implications for axonal protection.</p

Radiation Produces Irreversible Chronic Dysfunction in the Submandibular Glands of the Rat

The exposure to high doses of ionizing radiation during radiotherapy results in severe morphological and functional alterations of the salivary glands, such as xerostomia. In the present study we investigated the chronic effect of a single radiation dose of 15 Gray (Gy) limited to head and neck on rat salivary gland function (salivary secretion and gland mass) and histology. Results indicate that norepinephrine (NE)-induced salivary secretion was reduced significantly at 30, 90, 180 and 365 days after the administration of a single dose of 15 Gy of ionizing radiation compared to non-irradiated animals. The maximal secretory response was reduced by 33% at 30 and 90 days post irradiation. Interestingly, a new fall in the salivary response to NE was observed at 180 days and was maintained at 365 days post irradiation, showing a 75% reduction in the maximal response. The functional fall of the salivary secretion observed at 180 days post irradiation was not only associated with a reduction of gland mass but also to an alteration of the epithelial architecture exhibiting a changed proportion of ducts and acini, loss of eosinophilic secretor granular material, and glandular vacuolization and fibrosis. On the basis of the presented results, we conclude that ionizing radiation produces irreversible and progressive alterations of submandibular gland (SMG) function and morphology that leads to a severe salivary hypo-function